Epigenetic regulation of S100 protein expression
نویسندگان
چکیده
منابع مشابه
Calcium-binding S100 protein expression in pterygium
PURPOSE Pterygium is an ocular surface disease of unknown etiology associated with epithelial and fibrovascular outgrowth from the conjunctiva onto the cornea. S100 proteins are calcium-activated signaling proteins that interact with other proteins to modulate biological functions such as cell migration, proliferation, and differentiation. The aim of this study was to investigate the presence o...
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Purpose The S100 fused-type proteins hornerin (HRNR) and filaggrin-2 (FLG2) are members of the epidermal differentiation complex, which is involved in terminal differentiation of keratinocytes via cornification as well as maintenance of the epidermal antimicrobial barrier. We investigated the expression and possible regulation of HRNR and FLG2 at the ocular surface and in the lacrimal apparatus...
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Regulatory T cells play important roles in the control of autoimmunity and maintenance of transplantation tolerance. Foxp3, a member of the forkhead/winged-helix family of transcription factors, acts as the master regulator for regulatory T-cell (Treg) development and function. Mutation of the Foxp3 gene causes the scurfy phenotype in mouse and IPEX syndrome (immune dysfunction, polyendocrinopa...
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The nucleus is a complex and highly compartmentalized organelle, which undergoes major organization changes during cell differentiation, allowing cells to become specialized and fulfill their functions. During terminal differentiation of the epidermal keratinocytes, the nucleus undergoes a programmed transformation from active status, associated with execution of the genetic programs of cornifi...
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There is a wealth of evidence from both epidemiological studies (Hales and Barker, 2001) and animal models (Tarry-Adkins and Ozanne, 2016) that environmental exposures during early mammalian development may alter developmental trajectories in a manner that results in altered disease susceptibility and stress responsiveness in later life. This phenomenology is termed 'developmental programming.'...
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ژورنال
عنوان ژورنال: Clinical Epigenetics
سال: 2011
ISSN: 1868-7075,1868-7083
DOI: 10.1007/s13148-011-0023-9